Ethoxybis(pentane-2,4-dionato-O,O')(propan-2-olato)titanium

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

short-term toxicity to aquatic invertebrates

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Justification for type of information:

As the target substance hydrolyses rapidly (half-life < 30 minutes) the intrinsic properties are related to hydrolysis products of the target substance. This information is used as a supporting evidence on the toxicity of the target substance in CSA.

Reference 2

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Justification for type of information:

pentane-2,4-dione is the hydrolysis prodcuts of the target substance. Properties of the the two substance are used for read-across.

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

GLP compliance:

not specified

Test organisms (species):

Daphnia magna

Test type:

static

Water media type:

freshwater

Total exposure duration:

48 h

Key result

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

ca. 48 mg/L

Nominal / measured:

meas. (not specified)

Conc. based on:

test mat.

Basis for effect:

mobility

Validity criteria fulfilled:

yes

Conclusions:

The 48h EC50 was 48 mg/l tested on Daphnia magna.

Reference 3

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Qualifier:

equivalent or similar to guideline

Guideline:

other: DIN 38412, Part 11

Principles of method if other than guideline:

Daphnien-Kurzzeittest, DIN 38412 Teil 11, Bestimmung der Wirkung von Wasserinhaltsstoffen auf Kleinkrebse

GLP compliance:

not specified

Analytical monitoring:

no

Vehicle:

no

Test organisms (species):

Daphnia magna

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

24 h

Key result

Duration:

24 h

Dose descriptor:

EC50

Effect conc.:

ca. 1 850 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Validity criteria fulfilled:

not applicable

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

48 mg/L

Additional information

No studies were conducted on the target substance. As the target substance hydrolyses rapidly (half-life < 30 minutes) the intrinsic properties are related to hydrolysis products of the target substance. 

On the basis that if entering the environmental, this substance will quickly dissociate to form the inorganic (poorly soluble) titanium dioxide and organic ethanol, 2-propanol and acetylacetone. The titanium dioxide is not considered further in this report as aquatic toxicity assessments do not apply. The short-term aquatic toxicity studies of acetylacetone and 2-propanol are well-investigated are used for CSA.