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EC number: 700-736-9
CAS number: 2149571-40-2
A study (Huntingdon Life Sciences, VHJ0047, 2013) was performed to
assess the skin sensitization potential of MTF using the local
lymph node assay (LLNA). The study comprised three treated groups, each
comprising four female mice receiving MTF
at concentrations of 10, 25 or 50% v/v.
Similarly constituted groups received the vehicle 4:1 v/v acetone: olive
oil (AOO) or positive control substance (25% v/v hexyl cinnamic
aldehyde). The mice were treated by daily application of 25 µL of the
appropriate concentration or control (vehicle or positive), to the
dorsal surface of both ears for three consecutive days.
MTF was regarded as a potential skin sensitizer. The EC3ex value was
calculated to be 8.3% v/v.
Migrated from Short description of key information:
The SI obtained for 10, 25 and 50% v/v was 3.8, 7.8, and 7.3 respectively which indicates that MTF showed the potential to induce skin sensitization.
The EC3ex value was calculated to be 8.3 % v/v.
As the EC3 value,obtained from the Local lymph node assay, was
calculated to be > 2 % the MTF will be classified as a skin sensitiser
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