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EC number: 700-736-9
CAS number: 2149571-40-2
An Acute Oral (9 females rats): LD50 = 1000mg/kg
An acute Dermal (5 males and 5 females rats): LD50 > 2000mg/kg
An acute oral toxicity study (Kumamoto Laboratory, 2009) was conducted
to assess the toxicity of MTF following a single oral administration to
The study was conducted according to OECD test guideline 423 and in
compliance with GLP.
A single dose of the test substance was administered by oral route to
female rats Crl:CD(SD) rats.
Dose levels in both experiments 1 and 2 were set at 300 mg/kg, and that
in experiment 3 was set at 2000 mg/kg. Three animals were used in each
experiment. Clininal observation and body weight measurement were
conducted during the observation period and necropsy was performed at
the completion of the observation period.
Three animals in experiment 3 (2000 mg/kg) died 2 days after
administration (day 3).
In observation for clinical signs, mucous stool or soiled periproctal
region was observed in experiments 1 and 2. Besides the findings,
hypoactivity, tremor, lateral position, or bradypnea was observed in
dead animal in experiment 3.
In surviving animals in experiments 1 and 2, mucous stool or soiled
periproctal region all disappeared by 2 days after administration.
There were also changes to the body weights after administration and in
An acute dermal toxicity study (Huntingdon Life Sciences, 2013) was
conducted to assess the toxicity of MTF following a single dermal
exposure to rats.
The study was conducted according to OECD test guideline 402, EC test
guideline B3, and US EPA OPPTS 870.1200, and in compliance with GLP.
A group of ten rats (five males and five females) received a single
topical application of the test substance, as supplied, at a dose level
of 2000 mg/kg bodyweight, for duration of 24 hours. The animals were
retained for a 14 day observation period during which clinical signs,
dermal reaction and bodyweight investigations were performed.
There were no deaths and no systemic response to treatment in any
animal. Very slight erythema (barely perceptible) was seen in four males
and five females. These reactions had resolved by Day 11. A bodyweight
loss was noted for four females on Day 15. All other animals were
considered to have achieved satisfactory bodyweight gains throughout the
study. No abnormalities were noted in any animal at the macroscopic
examination at study termination on Day 15.
No inhaled toxicity study was conducted, as the requirement for an acute
toxicity study by a second route of exposure was satisfied by the dermal
toxicity study, noted above. It is considered unlikely that MTF will be
available in a vapour or other airborne / inhalable state.
The LD50 by oral administration was determined to be 1000 mg/kg
bodyweight in rats.
According to the CLP Regulation (Regulation (EC) 1272/2008),
classification as Acute Toxiticy Category IV applies when the LD50 is
greater than 300 mg/kg but equal to or less than 2000 mg/kg. On this
basis, MTF, will be calssified Acute Toxicity (oral) category IV; the
signal word "Warning" and the Hazard statement "H302: Harmful if
swallowed" are applicable. The corresponding classification according to
the Dangerous Substances Directive (Directive 67/548/EEC, DSD) is "R22,
Harmful if swallowed", applicable when the acute oral LD50 is between
200 and 2000 mg/kg.
The LD50 by dermal administration to rats was determined to be greater
than 2000 mg/kg; on this basis no classification is required for dermal
toxicity according to either the CLP regulation, or the DSD.
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