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EC number: 226-789-3
CAS number: 5468-75-7
- results without metabolic activation were
negative in two replicates, the tested concentrations were non-toxic
Trial 1 (mean mutant frequency): 36, 40, 44,
40 and 46 at 0.03, 0.06, 0.125, 0.25 and 0.5 µg/ml; DMSO control: 31
Trial 2 (mean mutant frequency): 30, 30, 45,
38 and 37 at 0.1, 0.2, 0.3, 0.4 and 0.5 µg/ml; DMSO control: 30
- with metabolic activation one trial
revealed increased mutant frequencies at concentrations >/= 0.2 µg/ml in
comparison to the vehicle control, but without dose response
relationship; in two further trials negative responses were observed
Trial 1 (mean mutant frequency): 25, 61, 68,
69 and 62 at 0.1, 0.2, 0.3, 0.4 and 0.5 µg/ml; DMSO control: 30
Trial 2 (mean mutant frequency): 48, 57, 62,
61 and 60 at 0.1, 0.2, 0.3, 0.4 and 0.5 µg/ml; DMSO control: 54
Trial 3 (mean mutant frequency): 79, 68, 76,
94 and 88 at 0.1, 0.2, 0.3, 0.4 and 0.5 µg/ml; DMSO control: 71
- solvent and positve controls were within
the normal range
Induction of mammalian cell gene mutations
in vitro has been investigated in mouse lymphoma L5178Y cells in the
presence (rat liver S9) and absence of metabolic activation. The test
item did not induce gene mutations in concentrations up to 0.5 µg/ml
under the tested conditions.
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