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EC number: 226-789-3
CAS number: 5468-75-7
The test material was non-irritant in in-vivo studies in rabbits
examining skin as well as eye irritation.
The test material was tested for skin irritancy according to FDA
guidelines. Both intact and scarified skin sites of six rabbits were
exposed to 0.5 ml test substance for 24 h under occlusive conditions and
the skin responses were watched for 48 hours after end of exposure. Very
slight erythema were noted in 5/6 animals immediately after end of
exposure, fully reversible in 4/6 animals by 48 h after end of exposure.
Very slight edema were noted in 5/6 animals immediately after end of
exposure, fully reversible by 48 h after end of exposure. Therefore, the
test item has not to be classified for skin irritation according to
Regulation (EC) No. 1272/2008.
The test material was tested for eye irritancy according to a procedure
described in the "Appraisal of the Safety of Chemicals in Foods, Drugs
and Cosmetics" (1959) of the US Association of Food and Drug Officials
(AFDO). 0.1 g neat test substance was applied to the conjunctival sac of
one eye each of 6 animals (no washing in 3 animals, group 1, washing
after 30 seconds in 3 animals, group 2) and eye responses were watched
for seven days. No eye responses were noted in any animal at any time
point. The test item is not irritating to eyes and has not to be
classified as irritating to eyes according to the criteria of Regulation
(EC) No 1272/2008.
Neither skin nor eye irritation were detected in in vivo studies in
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