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EC number: 226-789-3
CAS number: 5468-75-7
Male and female Tif. RAI rats were subjected to test acute oral
toxicity. The test substance was administered by gavage at dose levels
up to the highest applicable dose of 10000 mg/kg bw. No animal died
under these conditions, thus leading to a LD50 > 10000 mg/kg bw. No
substance related gross organ changes were seen at necropsy.
Acute inhalation toxicity of the test item has been investigated in male
and female Tif: RAIf (SPF) rats (10 per sex). They were exposed to 4250
mg test substance per cubic meter for 4 h (maximal applicable dose). All
animals survived the 14 day observation period. No macroscopic visible
changes were observed at necropsy at the end of the observation period,
resulting in a LC50 value of > 4250 mg/m³ (4.25 mg/L) for the inhalation
Acute dermal toxicity of the test item was tested in male and female
Sprague-Dawley rats. The maximal applicable dose (3 g test item /kg bw
suspended in polyethylene glycol:water 50:50 - final volume 9.9 ml;
corresponding to 1710 mg/kg bw) were applied to the skin. No clinical
signs were observed and no animals died during the 7 day observation
period, resulting in a LD50 > 3000 mg/kg bw (corresponding to > 1710
- within 2 hours after treatment, all treated animals showed dyspnoea,
exophthalmus, curved position and ruffled fur
- in the higher dose (10 g/kg bw) these symptoms became more accentuated
- all animals recovered within 3 to 6 days
- animals were sacrificed at day 7, but no substance related gross organ
changes were seen
Classification for acute oral toxicity is not necessary according to
Regulation (EC) No 1272/2008.
Classification for acute inhalation toxicity
is not necessary according to Regulation (EC) No 1272/2008 .
No adverse effects were observed after acute oral d3eremal or inhalation
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