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EC number: 226-789-3
CAS number: 5468-75-7
Based on the available
data base on C.I. Pigment Yellow 14 relevant information exists to make
a qualitative evaluation of the toxicokinetic profile of this compound.
This is in line with animal welfare considerations because additional
animal tests can be avoided by such an evaluation. The substance is
available in nano-form. The available data have partly been generated
with non-specified material, but the conclusions drawn are considered
valid for the nano form as well, because the material is chemically
identical, and the physical properties are widely overlapping.
The results of basic
toxicity testing give no reason to anticipate unusual characteristics
regarding the toxico-kinetics of C.I. Pigment Yellow 14. C.I. Pigment
Yellow 14 is not absorbed from the gastro-intestinal tract in
toxicologically significant amounts. The data indicate that there is no
relevant dermal absorption. After inhalation unspecific reactions to
unreactive dust can be expected. Indications of a bio-accumulative
potential as well as metabolism towards genotoxic sub-structures do not
exist. Excretion of traces of possibly systemically available C.I.
Pigment Yellow 14 and/or metabolites via faeces is likely.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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