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EC number: 226-789-3
CAS number: 5468-75-7
1: Acute immobilisation of daphnia after 24 and 48 hours in the limit
Response at 24 h
Response at 48 h
0.45 µm filtrate.
Table 2: reference substance
immobilization of daphnia alter 24 and 48 hours in the reference test
Expected response (%)After 48 hours1
on historical data of the previous years (n>60).
maximum response of 10% does not invalidate the results of the test.
The effects of the submission substance on
Daphnia magna straus had been tested according to the
ISO International Standard
"Water quality Determination of the inhibition of the mobility of Daphnia
toxicity test, Third edition, 1996-04-01 and equivalent to OECD 202 and
EU-method C.2. The test fulfilled all the validity criteria and is of
reliability category 1.
Because of the
insolubility of the submission substance in water (< 10 µg/L), a nominal
concentration of 100 mg/L had been used after filtration (0.45 µm
membrane filter) and analytical monitoring had not been possible becaus
of sensitivity limitations.
At the test concentration, no immobilization of daphnids could be
observed. The nominal test concentration of 100 mg/L of the submission
substance is therefore the NOEC (48h).
The test item was tested for toxicity on Daphnia magna (Straus) in an
acute immobilization test according to OECD 202 and compliant to GLP
(reliability 2). EC10 and EC50 (both 24 and 48 hours) had been
determined to be larger than the highest tested nominal concentration of
1000 mg/L. The test was performed as semistatic (change of the test
medium after 24h). The actual concentration was verified by measurement
of total carbon and for the two highest test concentration showed to be
within 95% of the nominal concentration. As the test item is an aqueous
dispersion of the submission substance with the submission substance
accounting for 39.6% of the test item, the results of the test based on
the content of the submission substance would be: EC10 and EC50 (both 24
and 48 hours) > 396 mg/L.
Under the conditions of the present test, the test substance induced no
effects in Daphnia magna exposed to a filtered solution prepared at a
loading of 100 mg/I (NOEC)
Two studies on the acute toxicity towards invertebrates (equivalent to
OECD 202 and according to OECD 202, respectively; reliability category
1) for Pigment Yellow 12 and its structural analogue, Pigment Yellow 13
are available. For both of these pigments consistently no toxicity to
Daphnia magna could be found in the tests. Nominal concentrations far
above the solubility limit of the pigments had been applied. Therefore,
the Diarylide Yellow Pigments are to be regarded as acutely nontoxic to
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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