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EC number: 226-789-3
CAS number: 5468-75-7
Staining by the test material prevented a
clinical assessment of erythema. Histopathological investigation
revealed a low grade skin irritation reaction: A predominantly minimal
to slight inflammatory reaction with acanthosis and inflammatory cell
infiltration was recorded in approximately equal proportions in skin
samples from control and test animals treated with 3%, 10% or 30% (w/v)
preparations of the test material in corn oil. There was considered to
be no significant difference in the frequency of this effect between
test and control samples. Following application of the 60% (w/v)
preparation in corn oil only a very minor effects was observed in the
Additional investigations were performed on
skin irritation potential of corn oil, the vehicle used in this study,
under Buehler challenge conditions. There were no skin reactions visible
on clinical examination. Histopathological findings were similar to
those reported in this test with the test item.
Histopathological examination revealed a background level of minimal irritation to the skin for all the concentrations used at challenge. There was considered to be no significant difference in the skin response between test and control animals. In a positive control study, challenge of previously induced guinea pigs with an undiluted preparation of hexylcinnamaldehyde elicited a moderate skin sensitisation response, confirming the validity of the assay.
Therefore, the test item has not to be classified as skin sensitiser according to Regulation (EC) No 1272/2008.
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