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EC number: 265-057-8
CAS number: 64741-56-6
A complex residuum from the vacuum distillation of the residuum from atmospheric distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly greater than C34 and boiling above approximately 495°C (923°F).
only difference observed between exposed and controls, was a slight
decrease in body temperature in the exposed animals (35.6 and 36.6°C in
males and females, respectively) compared with the controls (37.3 and
37.7°C in males and females, respectively). None of the investigated
reflexes had been influenced by the treatment at any timepoint.
temperature bitumens are solid or semi-solid. For most applications,
materials are handled at elevated temperatures which makes thermal burns
the greatest acute hazard. No acute inhalation toxicity data are
available for straight-run bitumen but a study has been performed on an
oxidized (air-rectified) asphalt which is used for read across. Read
across of oxidised asphalt to straight run bitumen is considered valid
since mild oxidation is not expected to change the composition or acute
toxicity of the material.
from oxidized (air-rectified asphalt) was tested in an OECD 403 study
under GLP conditions (Fraunhofer, 2000). The fumes were collected from
storage tanks containing commercial product, condensed and regenerated
in the laboratory under well defined conditions. Wistar rats (5 males
and 5 females) were nose-only exposed to regenerated fume or clean air
for 4.5 h (half an hour longer than the standard 4 h to achieve the
desired exposure concentration during 4 h) and subsequently housed
individually for 2 weeks. The exposure concentration was 94.4±7.7 mg/m3
as total hydrocarbon with a number median aerodynamic diameter (NMAD) as
measured with the SMPS - system (scanning mobility particle seizer) of
85 nm. All animals were observed for clinical and behavioural signs
during the exposure, several times after the termination of exposure on
the day of exposure and daily on all the subsequent days. Body weights
were recorded on day 0, 3, 7 and 14. At the end of the study the animals
were sacrificed and subject to gross pathology. No clinical signs of
intoxication were observed at any time. No effects on any of the
reflexes tested were observed at any time. Also no differences in body
weight were observed between exposed and controls nor were any gross
abnormalities found upon necropsy. The only difference observed between
exposed and controls, was a slight decrease in body temperature in the
exposed animals (35.6 and 36.6°C in males and females, respectively)
compared with the controls (37.3 and 37.7°C in males and females,
respectively). The LC50 was found to be > 94.4 mg/m3 (4 hours).
This study received a
Klimisch score of one and is classified as reliable with restriction
was conducted according to or similar to guideline study OECD TG 403.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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