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EC number: 265-057-8
CAS number: 64741-56-6
A complex residuum from the vacuum distillation of the residuum from atmospheric distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly greater than C34 and boiling above approximately 495°C (923°F).
Group mean bodyweight data (+/- SD) n = 21-24
- Test: Dunnett 5% significance level
** - Test:
Dunnett 1% significance level
Table 2 Ceasaren Section Data
Generalised Results - Group Summary by Mixed Parameter / Time
Number of Females Pregnant
Dams with Viable Fetuses
No. Corpora Lutea/Grp
Dunnett 5% significance
Factor Test: Chi-squared p < 0.05
Dunnett 1% significance
The maternal NOAEL was determined to be the low dose group, 50 mg/m³.
Observations at 500 mg/m³ included effects on body weight, food
consumption, lung weight and histopathological changes in the lung and
larynx. At 150 mg/m³ observations were restricted to histopathological
changes in the larynx.
The developmental NOAEL was the medium dose group, 150 mg/m³, due to
reduced fetal weight at 500 mg/m³.
Importantly, nose-only exposure to bitumen fumes in concentrations up to
500 mg/m³ from p.c days 1 to 19, did not induce any fetal anomalies
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