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EC number: 265-057-8
CAS number: 64741-56-6
A complex residuum from the vacuum distillation of the residuum from atmospheric distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly greater than C34 and boiling above approximately 495°C (923°F).
In an in-vitro dermal absorption study, 200 ul aliquots of neat bituen
fume condensate, containing low concentrations of PACs, was applied to
the surface of human skin samples fixed in a Franz Diffusion cell.
Samples of the receptor fluid were analysed at time intervals ovr a 48hr
period following application.
Results show that PACs present in bitumen fume condensate can penetrate
The rate of dermal flux (ng/cm²/hr±SD) for selected PACs was:
anthracene 6.5 ± 0.9; fluoranthene-pyrene 1.8 ± 0.3;
whilst the rate for total 3-6 ring PAC was 120 ± 30.
The amount absorbed over a 48hr period was relatively low; measured
values compared to aapplied dose were
anthracene 5.3%, fluoranthene-pyrene 3.3% and 3-6 ring PAC 1.8%.
The permeability coefficient Kp (Kp = flux rate/applied concentration) for anthracene was
calculated to be 2 x 10-4 cm/hr.
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