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EC number: 265-078-2
CAS number: 64741-77-1
A complex combination of hydrocarbons from distillation of the products from a hydrocracking process. It consists predominantly of saturated hydrocarbons having carbon numbers predominantly in the range of C10 through C18, and boiling in the range of approximately 160°C to 320°C (320°F to 608°F).
In a 90 -day dermal toxicity study, Vacuum
Tower Overheads were applied to the shaved skin of 30 young adult male
and female Sprague-Dawley rats at dose levels 0, 30, 125, and 500
mg/kg/day for 5 days/week during a 90 -day period.
The dermal application of Vacuum Tower
Overheads was found to affect both haematology and serum parameters as
well as the body, thymus and liver weights of exposed animals. The
adverse effects on the thymus had been reported in other studies
referenced in this study report. No treatment-related effects were noted
on examination of the weight of epididymides, ovaries, prostate, testes
or uterus nor in the histopathology of the ovaries and testes nor in the
number of epididymal sperm, sperm/g cauda epididymis, number of abnormal
and normal sperm, number of testicular spermatids, and sperm/g testis.
The NOAEL has been reported as 30 mg/kg/day.
This study is classified as reliable with
restrictions because it is an acceptable and a well-documented study
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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