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EC number: 265-078-2
CAS number: 64741-77-1
A complex combination of hydrocarbons from distillation of the products from a hydrocracking process. It consists predominantly of saturated hydrocarbons having carbon numbers predominantly in the range of C10 through C18, and boiling in the range of approximately 160°C to 320°C (320°F to 608°F).
Average Dermal Irritation Score
API #79 -6
Induction Phase Average
Challenge Phase Average
In a skin sensitisation study, ten young
adult male albino guinea pigs were exposed to 0.5 mL of undiluted diesel
fuel (marketplace sample) in the treatment group and ten young adult
male albino guinea pigs were exposed to 0.05% (w/v) dilution of
chlorodinitrobenzene in ethanol in the positive control group. Both
groups were shaved in an area on their back. On the day of application,
test material or positive control was placed on a gauze patch which was
put on the shaved exposure site, covered with plastic wrap and wrapped
with elastic bandaging. Bandaging and wrapping was removed 6 hours after
application. The same procedure was replicated 3 times a week for 3
weeks (10 treatments in total). Two weeks after the last induction dose,
a single challenge dose was administered following the same methods as
used during the induction period, in both the treatment and positive
control groups. Scoring of erythema and oedema was made at 24 hours
after each application.
Results indicated no statistically
significant differences between the mean of the averages of the ten
sensitizing treatments and the mean of the challenge treatment for
wither erythema or oedema in the test or control group. Based on this
data, the test material is considered non-sensitising.
This study received a Klimisch score of 2
and is classified as reliable with restrictions because it was conducted
similar to guideline study OECD 406.
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