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EC number: 265-078-2
CAS number: 64741-77-1
A complex combination of hydrocarbons from distillation of the products from a hydrocracking process. It consists predominantly of saturated hydrocarbons having carbon numbers predominantly in the range of C10 through C18, and boiling in the range of approximately 160°C to 320°C (320°F to 608°F).
In an acute dermal toxicity study, 4 male
and 4 female New Zealand white rabbits were shaved 24 hours prior to
application of test material. This area constituted 30% of the total
body surface area. Afterwards, the animals were returned to their stock
cages for 24 hours to allow the skin to heal. On testing day, the
exposure sites of four animals (2 males and 2 females) were abraded.
Minor abrasions were made through the stratum corneum, but not the
dermis. A single dose of 5 mL of undiluted test material per kilogram
body weight was applied to gauze sponges backed with plastic wrap to
help prevent evaporation of the test material. The sponges and plastic
wrap were then taped to the shaved area of the rabbit's backs with
adhesive tapes. The entire trunk was wrapped with elastic tape and the
rabbits were then returned to their cages. After 24 hours, the bandaging
was removed and the skin wiped with gauze sponges to remove excess test
material. Animals were observed for mortality, local reactions, and
behavioural abnormalities daily for 14 days. Body weights were recorded
on days 0, 7, and 14. on day 14 all surviving rabbits were subjected to
During the 14 day study, erythema followed
by a drying and flaking of the skin was observed at the test site in all
test rabbits. No signs of systemic toxicity were noted. None of the
rabbits lost weight during the testing period. The gross post-mortem
examinations at 14 days revealed four rabbits with congested kidneys,
two with haemorrhages in the trachea, and one with a congested liver.
None of these observations were found to be treatment-related. The test
material is classified as practically nontoxic.
This study has a Klimisch score of 1 and is
classified as reliable without restriction because it was conducted
according to or similar to guideline study OECD 434.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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