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EC number: 265-078-2
CAS number: 64741-77-1
A complex combination of hydrocarbons from distillation of the products from a hydrocracking process. It consists predominantly of saturated hydrocarbons having carbon numbers predominantly in the range of C10 through C18, and boiling in the range of approximately 160°C to 320°C (320°F to 608°F).
VGO/HGO/Distillate fuels were found to be irritating to the skin of rabbits after a 24-hour, occlusive exposure (similar to OECD 404). The key data showed a mean erythema score of 3.9 and a mean oedema score of 2.96.
VGO/HGO/Distillate fuels were considered non-irritating to the rabbit eye (OECD 405).
studies were available to assess the skin irritation potential of
VGOs/HGOs/Distillate fuels. In
the key study (Klimisch score = 1, API 1980a), the irritation potential
of diesel fuel to rabbits was evaluated after application to one abraded
area and one intact area per animal, under occlusion, for 24 hours. Pronounced
erythema and oedema were present at both abraded and intact test sites
at 24 hours, with blistering and peeling. The
erythema was largely resolved by day 14, and the oedema was fully
resolved by day 14. The
mean 24 and 72 hour score for erythema was 3.9 and oedema was 2.96.
supporting studies, rabbits were dermally exposed to VGOs/HGOs/Distillate
fuelsunder occlusive conditions for 24
hours (Klimisch scores = 2, API 1980b, ARCO 1993e, 1993f, 1990b, 1988e,
1987j, 1987k, 1986b, 1986c). Mean
erythema scores ranged from 1.5 to 3.25, and mean oedema scores ranged
from 1.2 to 2.65. Another supporting study (Klimisch score
= 2, API 1980), yielded a primary irritation score of 3.37, finding the
substance to be moderately irritating.
studies were performed with a 24 hour exposure rather than 4 hours
recommended by the current OECD guidelines. Consequently, the result
from a shorter exposure time will likely not cause as much irritation as
these records indicate. However,
based on these results and evidence of irritation in all studies,
VGOs/HGOs/Distillate fuels are classified as irritating to the skin.
studies were available to assess the eye irritation potential of
VGOs/HGOs/Distillate fuels. In
the key study, 9 New Zealand White rabbits (5 males and 4 females)
received 0.1 mL of undiluted test material in the right eye. Treated
and control eyes from three rabbits from each study were flushed with
lukewarm water for one minute starting 30 seconds after test material
instillation. The eyes of the other 6 rabbits in each study remained
the key study (Klimisch score = 1, API 1980a), diesel fuel was
non-irritating to the eyes of rabbits. Under
the conditions of this study, the test material exhibited no corneal
opacity and the slight irritation was reversible within seven days,
indicating a non-irritating response.
additional eye irritation supporting studies (Klimisch scores = 2, API 1980b,
ARCO 1993g, 1992d, 1990c, 1988f, 1987l, 1986g, 1986e, 1986f; API 1980),
rabbits were exposed toVGOs/HGOs/Distillate
fuelsand observed for irritation. Any
irritation noted was fully reversible and mild.
on these results,VGOs/HGOs/Distillate
fuelsare not classified as irritating
to the rabbit eye.
Justification for selection of skin irritation / corrosion endpoint:
one of 12 studies on materials from the VHGO category
Justification for selection of eye irritation endpoint:
one of twelve studies, none of which showed no more than minimal transient irritation
Effects on skin irritation/corrosion: irritating
mean erythema scores of 3.9 (24, 72 hours), and mean oedema scores of
2.96 (24, 72 hours), VGOs/HGOs/Distillate Fuels are classified as
irritating to the skin, H315, according to the EU CLP Regulation (EC)
Based on a
lack of significant eye irritation, VGOs/HGOs/Distillate Fuels are not
classified as irritating to eyes according to the EU CLP Regulation (EC)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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