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EC number: 265-078-2
CAS number: 64741-77-1
A complex combination of hydrocarbons from distillation of the products from a hydrocracking process. It consists predominantly of saturated hydrocarbons having carbon numbers predominantly in the range of C10 through C18, and boiling in the range of approximately 160°C to 320°C (320°F to 608°F).
Primary dermal irritation score: 6.81
In an skin irritation study, 3 male and 3
female New Zealand White rabbits were exposed to diesel fuel (market
place sample). Before test material application, each animals was
clipped of hair in an area from the shoulders to the hips and halfway
down either side of the thorax. There were four exposure sites per
animals (2 on each side of the midline). On the day of the study, the
left posterior and right anterior site on each animal was abraded.
Incisions penetrated the stratum corneum, but not the dermis. The
remaining test sites were left in tact. 0.5 mL of test material was
applied to gauze patches backed by plastic wrap. The patches were
applied to the four test sites and were secured in place with bandage
strips and elastic tape. After 24 hours, the wrapping and patches were
removed. Excess test material was removed by wiping the skin with gauze
sponges. Observations for erythema and oedema were recorded at 24 and 72
hours, and 7 and 14 days post-application. Erythema and oedema were
scored using the Draize method.
At 24 hours the test sites were very
irritated. Blisters formed, some open and with skin peeled back. At 72
hours, the sites remained very irritated, two rabbits had open sores. By
day 7 most of the sites had formed scabs. By the 14th day, the skin was
healing, but still dry and flaky with no hair growth on the test sites.
The mean erythema and oedema scores for 24 and 72 hours are 3.9 and
2.96, respectively. Diesel fuel is classified as an irritant.
This study received a Klimisch score of 2
and is classified as reliable with restrictions because it is an
acceptable and a well-documented study report.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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