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EC number: 265-078-2
CAS number: 64741-77-1
A complex combination of hydrocarbons from distillation of the products from a hydrocracking process. It consists predominantly of saturated hydrocarbons having carbon numbers predominantly in the range of C10 through C18, and boiling in the range of approximately 160°C to 320°C (320°F to 608°F).
In a micronucleus assay, fifteen male and
female CD-1 mice were treated with 1.0, 2.5, or 5.0 g/kg of home heating
oil dissolved in corn oil via oral gavage. A concurrent control group
received only corn oil, while another group served as positive control
and was treated with 0.04 g/kg cyclophosphamide.
Five male and female mice from each dose
group were sacrificed 24, 48 or 72 hours after test material
administration. Bone marrows were removed and examined for the presence
of micronuclei. Mice treated with cyclophosphamide were sacrificed 24
hours after administration. The micronucleus assay was conducted using
the Schmid method. Erythrocytes numbering 1,000, were counted for each
animal bone marrow slide and the number of polychromatic (PCE) and
normochromatic (NCE) erythrocytes were tabulated. Frequency of
micronucleus induction was determined by examining the number of
micronuclei per 1,000 PCEs.
There was no increase in the frequency of
micronuclei for the test material. In addition, there was no evidence of
bone marrow depression. Cyclophosphamide, the positive control,
exhibited appropriate results and the vehicle control result was within
the normal range. Based on these results the study authors concluded
home heating oil did not exhibit a positive response.
This study received a Klimisch rating of
“reliable with restrictions” because, though it does not follow a
prescribed guideline, it is well conducted and reported.
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