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EC number: 265-078-2
CAS number: 64741-77-1
A complex combination of hydrocarbons from distillation of the products from a hydrocracking process. It consists predominantly of saturated hydrocarbons having carbon numbers predominantly in the range of C10 through C18, and boiling in the range of approximately 160°C to 320°C (320°F to 608°F).
Acute Oral Toxicity:
Acute oral toxicity of #2 home heating oil, was evaluated in male and
female rats following a single oral gavage administration of the test
material at different concentrations (similar to OECD 401). The LD50
for #2 home heating oil is 21.1 mL/kg body weight (approx 17,900 mg/kg).
Based on all acute oral toxicity studies, the LD50 for
VGOs/HGOs/Distillate fuels is > 5000 mg/kg bw.
Acute Inhalation Toxicity:
Acute inhalation toxicity of naval distillate in male and female rats
was evaluated in a study involving whole-body exposure for 4 hours
(similar to OECD 403). The acute inhalation LC50 was 4.1 mg/L .
Acute Dermal Toxicity:
In an acute dermal toxicity study, male and female New Zealand White
rabbits were exposed to #2 home heating oil for 24 hours at a dose level
of 5 mL/kg (approx 4300 mg/kg). The animals were then observed for 14
days (similar to OECD 402). Based on this study, the acute dermal LD50
is > 4300 mg/kg.
a key study ( API 1980a) the acute oral toxicity of #2
home heating oil
was investigated. Undiluted
material was administered to Sprague Dawley rats by gavage at doses of
10, 20, 22.5, 23, or 25 mL/kg body weight by gavage. In the animals
administered #2 home heating oil, signs of toxicity were observed in all
dose groups while severity also increased with increased dose. Under
the conditions of this study, #2 home heating oil had an oral LD50
21.1 mL/kg bw (approx 17,900 mg/kg).
supporting studies conducted on numerous samples of the VGO/HGO/Distillate
fuels category ( API 1980b, ARCO
1993a, 1993b, 1992a, 1987a, 1987b, 1987c, 1987d, 1985, 1973a; API
1980), rats were administered single oral gavage doses ranging from 1000
mg/kg to 11,400 mg/kg bw. LD50s
for all studies were > 5000 mg/kg for males and females.
on these studies, the oral LD50 for VGOs/HGOs/Distillate fuels is > 5000
key study investigated the effects of inhalation of naval distillate in
male and female Sprague Dawley rats exposed by aerosol for 4 hours via
whole body exposure at measured concentrations of 2.3, 3.5, or 4.9 mg/L
aerosol (Klimisch score = 1, ARCO, 1988a). Animals were observed for 14
days. Clinical signs commonly included labored breathing and discharge
from the nose and eyes. Decreased activity and mobility was reported at
all concentrations during exposure. Macroscopic and microscopic findings
included discoloration of the lungs and red staining around the snout of
spontaneously dying animals. During the observation period, mortality
was observed in 0 of 10, 4 of 10, and 4 of 10 male rats at measured
exposures of 2.3, 3.5, and 4.9 mg/L, respectively. In females, mortality
was observed in 1 of 10, 7 of 10, and 6 of 10 animals at the measured
exposures of 2.3, 3.5, and 4.9 mg/L, respectively. The inhalation LC50
was determined to be 5.4 mg/L in males, 3.6 mg/L in females, and 4.1
mg/L in combined sexes.
acute inhalation studies were performed on numerous samples of the VGO/HGO/SRGO/Distillate
fuels category. These
can be used to support the conclusions of the key study, which serves as
a worst case scenario and provides an LC50 that can be used for
classification purposes. In
the supporting studies, rats were exposed via inhalation to VGOs/HGOs/Distillate
fuels for 4 hours(Klimisch scores = 1). In
general, LC50s as measured based on mortality and systemic effects were
> 5.00 mg/L for aerosols (ARCO 1992b, 1988b, 1988c, 1988d, 1987e).
on results of these studies,VGOs/HGOs/Distillate
fuelsare classified as harmful by
inhalation with an LC50 of 4.1 mg/L (aerosol).
studies were available to assess the acute dermal toxicity of
VGOs/HGOs/Distillate fuels. In the key study (Klimisch score = 1, API
1980b), the acute dermal toxic effects of #2 home heating oil were
investigated. The study used eight New Zealand White rabbits (4 male/4
female) receiving 5 mL of applied test material. Test material was
applied under occlusive dressing to groups of 4 animals on intact or
abraded skin. No
signs of systemic toxicity were observed. Based on the lack of
mortality, the LD50 is > 4300 mg/kg bw/day and the test material is not
classified for acute dermal toxicity.
supporting studies conducted on VGOs/HGOs/Distillate
fuels(API 1980a, ARCO 1993d, 1992c,
1990a, 1987f, 1987g, 1987h, 1987i, 1986a), rabbits were administered
single dermal doses of 2000 mg/kg bw or more (one study administered a
dose of 1800 mg/kg bw). LD50s
for all studies were greater than the maximum dose administered.
In other acute dermal supporting studies (Klimisch score - 2, API 1980a,
b), animals were administered a single dose of 5 mL/kg bw, which caused
skin irritation and resulted in no obvious signs of toxicity during the
14-day observation period or at necropsy in the species examined.
on results of these studies, the dermal LD50
for VGOs/HGOs/Distillate fuels is > 4300 mg/kg bw.
Justification for selection of acute toxicity – oral endpoint
One of twelve acute oral toxicity studies, all showing LD50 values
greater than 5000 mg/kg
Justification for selection of acute toxicity – inhalation endpoint
One of nine studies on members of the VHGO category
Justification for selection of acute toxicity – dermal endpoint
One of twelve acute dermal studies on VHGO category members
Fuels are not classified for acute oral toxicity based on an oral LD50 >
5000 mg/kg bw,
according to the EU CLP Regulation (EC)1272/2008.
Based on acute inhalation data, VGOs/HGOs/Distillate Fuels are
classified as H332 (harmful by inhalation) with an LC50 of 4.1 mg/L for
male and female rats,
according to the EU CLP Regulation (EC) 1272/2008.
VGOs/HGOs/Distillate Fuels are not classified for acute dermal toxicity
based on a dermal LD50 of > 4300 mg/kg body weight for male and
female rabbits, respectively,
according to the EU CLP Regulation (EC) 1272/2008.
classification and labelling for aspiration toxicity relies on the
measured or calculated kinematic viscosity of a substance at 40°C rather
than results from toxicological studies with animals. Hydrocarbons with
kinematic viscosities less than or equal to 20.5 mms/sec are classified
for aspiration toxicity according to the EU CLP Regulation (EC)
members of this
category may exist as low viscosity liquids that meet these criteria,
substances in this category are
classified for aspiration hazard unless the viscosity at 40oC
is greater than the regulatory thresholds based on the measured or
calculated kinematic viscosities.
Vacuum gas oils,
hydrocracked gas oils, and distillate fuels having a kinematic viscosity
mm2/s at 40°C would meet classification criteria as
aspiration hazard (H304) under CLP.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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