Registration Dossier
Registration Dossier
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EC number: 260-906-9 | CAS number: 57693-14-8
Endpoint summary
Administrative data
Description of key information
Skin sensitising.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
Two studies according to OECD guideline 406 were available. Both available studies indicate that test substance is a strong sensitiser by inducing skin hypersensitvity in 80 to 100 % of the treated animals, responding to an intrademal induction of 5 % in water or physiological saline.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
According to the CLP regulation (EC 1272/2008), based on a Guinea pig maximisation test, classification in category 1A applies if:
≥ 30 % responding at ≤ 0,1 % intradermal induction dose or ≥ 60 % responding at > 0.1 % to ≤ 1 % intradermal induction dose
and classification in category 1B applies if:
≥ 30 % to < 60 % responding at > 0.1 % to ≤ 1 % intradermal induction dose or ≥ 30 % responding at > 1 % intradermal induction dose.
Based on a positive response in 80 to 100 % animals responding to an intradermal induction at 5%, classification in category 1B applies.
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