Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Skin sensitising.

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

Two studies according to OECD guideline 406 were available. Both available studies indicate that test substance is a strong sensitiser by inducing skin hypersensitvity in 80 to 100 % of the treated animals, responding to an intrademal induction of 5 % in water or physiological saline.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

According to the CLP regulation (EC 1272/2008), based on a Guinea pig maximisation test, classification in category 1A applies if:

≥ 30 % responding at ≤ 0,1 % intradermal induction dose or ≥ 60 % responding at > 0.1 % to ≤ 1 % intradermal induction dose

and classification in category 1B applies if:

≥ 30 % to < 60 % responding at > 0.1 % to ≤ 1 % intradermal induction dose or ≥ 30 % responding at > 1 % intradermal induction dose.

Based on a positive response in 80 to 100 % animals responding to an intradermal induction at 5%, classification in category 1B applies.