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EC number: 260-906-9
CAS number: 57693-14-8
After short term skin exposure no adverse
effects were recorded.
Exposure of eyes resulted in severe
irritation in some cases with permanent effects.
Skin irritation: all available studies
indicate no potential of the test material for skin irritation
Eye irritation: several old studies with
limited documentation are available that indicate no eye irritation
potential of the test material. However, in one old and one recent study
moderate to severe effects were documented. The older study was
disregarded because the report gave no information on the purity of the
tested sample and the effects reported were not supported by other
The most recent study was selected as key
study and indicates a moderate irritation hazard.
Based on criteria in the CLP Regulation
(EC 1272/2008), a susbtance is classified as:
irritating to skin (category 2), if, when
applied on skin of an animal, a substance produces:
- mean value of ≥ 2.3 - ≤ 4.0 for
erythema/ eschar or for oedema in at least 2 of 3 tested animals from
gradings at 24, 48 and 72 hours after patch removal or, if reactions are
delayed, from grades on 3 consecutive days after the onset of skin
- inflammation that persists to the end of
the observation period normally 14 days in at least 2 animals,
particularly taking into account alopecia (limited area),
hyperkeratosis, hyperplasia, and scaling; or
- in some cases where there is pronounced
variability of response among animals, with very definite positive
effects related to chemical exposure in a single animal but less than
the criteria above.
irritating to eyes (category 2) if, when
applied to the eye of an animal, a substance produces:
— at least in 2 of 3 tested animals, a
positive response of: corneal opacity ≥ 1 and/or iritis ≥ 1, and/or
conjunctival redness ≥ 2 and/or conjunctival oedema (chemosis) ≥ 2
calculated as the mean scores following grading at 24, 48 and 72 hours
after installation of the test material, and which fully reverses within
an observation period of 21 days
the substance is not classified as skin
Based on effects reported in the key
studies, the substance is not classified for skin irritation while it is
classified as eye irritant, category 2 (H319).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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