Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 235-727-4
CAS number: 12626-81-2
Male rats were administered lead acetate in drinking water at
concentrations of 0, 0.25, 0.5, and 1 g/L over 60 days and biochemical
and histopathological analyses were performed on the tests. Body weight
was statistically significantly decreased at all tested doses.
Testicular weight was statistically significantly decreased at 1 g/L.
There were statistically significant increases in blood and testicular
lead concentrations, urinary δ-aminolevulinic acid (ALA), and testicular
cholesterol at all tested doses. There was a statistically significant
decrease in testicular ascorbic acid at all tested doses. There were
significant decreases in seminiferous tubule diameter and spermatid
count at 0.5 g/L and above, and in spermatogenic count and Leydig cell
number and nuclear diameter at 1 g/L. Spermatocytes and spermatids were
in degenerative condition, and the lumen of the seminiferous tubules was
filled with cellular debris at 0.5 g/L. At 1 g/L, the cellular pattern
of the seminiferous tubules was disintegrated, spermatogenic inhibition
was at the stage of spermatogonia, and Leydig cells were in atrophic
condition. The reproductive NOAEL and systemic LOAEL from this study
were both 0.25 g/L. The authors stated that high levels of cholesterol
and decreased ascorbic acid along with atrophic Leydig cells in animals
exposed to 1 g/L suggests non-utilization of cholesterol towards the
synthesis of testosterone from Leydig cells. They concluded that lead
may inhibit spermatogenesis at the pre-meiotic stage via lack of
testosterone production from Leydig cells.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again