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EC number: 235-727-4
CAS number: 12626-81-2
The genotoxic profile of lead is mixed. Bacterial mutagenesis
assays produce negative results while conflicting (positive and
negative) observations have been made in mammalian cell mutagenesis
systems. In the absence of confirmation that lead was in fact taken up
by bacteria, negative results in bacterial systems will not be assigned
significance in a weight of evidence evaluation.
Although lead may be capable of inducing genotoxicity by multiple
mechanisms, it is not yet possible to ascertain which mechanism, or
group of mechanisms, is of greatest importance and/or of physiological
relevance in producing the spectrum of changes suggested by in vitro studies.
Short description of key information:
Although lead genotoxicity can be induced in vitro, responses appear to be induced by indirect mechanisms and at very high concentrations that lack physiological relevance.
Endpoint Conclusion: No adverse effect observed (negative)
Exposure to Lead up to standard limit
concentrations in tests does not lead to genetic toxicity.
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