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EC number: 235-727-4
CAS number: 12626-81-2
This study assessed the in vitro absorption of lead oxide in
human skin samples at 0, 111, and 1033 µg/cm2 concentrations over 24
hours. For the 111 µg/cm^2 dose, 95.63% of the applied lead was
removed during the wash at 6 hours post-exposure. At 24 hours
post-exposure, 99.51% of the applied dose was not absorbed. The absorbed
dose into the receptor fluid was <0.01% (5 ng/cm^2) and the dermal
delivery was 0.13% (148 mg/cm^2) of the applied dose. For the 1033
µg/cm^2 dose, 96.10% of the applied lead was removed during the wash at
6 hours post-exposure. At 24 hours post-exposure, 98.28% of the applied
dose was not absorbed. The absorbed dose was <0.01% (10 ng/cm^2) and the
dermal delivery was 0.05% (479 ng/cm^2) of the applied dose. The authors
concluded that the apparent decrease in absorption as a function of dose
may be attributable to the considerable background from endogenous lead
in the donor skin restricting the reliability of the absorption factor
at the low dose.
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