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EC number: 235-727-4
CAS number: 12626-81-2
The humoral immunity of newborn mice exposed for 28 days to 2.5 mg/m3
aerosolized Pb(NO3)2 (Pb28-aero) or of 2 -week-old mice similarly
exposed for 14 days (Pb14-aer) was compared with that of both 2
-week-old mice given 125ug Pb(NO3)2/day by gastric intubation for 14
days (Pb14 -oral) and of 4 -week-old nonexposed controls. Mice from each
group were immunized with 10 to the eight sheep red blood cells by
intravenous (iv), intraperitoneal (ip), or intratracheal (it) routes of
immunization. Immunity was assessed by both hemagglutination and the
enumeration of antibody-forming cells from the spleen and thoracic lymph
nodes. All treatment groups had decreased thymus/body weight and
spleen/body weight ratios whereas only Pb-aero groups had enlarged
livers. The most significant immunosuppression occurred in the
ip-immunized Pb28 -aero group. A significant suppression of humoral
immunity was also observed in thoracic lymph node samples from Pbaero
groups immunized it or iv. There was no apparent immunosuppression in
any treatment group after iv immunization. These results indicate that
aerosolized lead is more immunosuppressive than equivalent amounts of
ingested lead. This is most likely due to the greater absorption of
inhaled lead and the subsequent cytotoxicity of lead for cells in the
draining lymph nodes.
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