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EC number: 235-727-4
CAS number: 12626-81-2
No allergic skin reactions occurred in test animals 24 and 48 hours
after the end of the challenge procedure. The sensitisation rate was 0%.
No findings were observed in control animals (reaction rate :0%).
The potential skin sensitising properties of the test article "LITHARGE
lead oxide" were assessed in the guinea pig maximisation sensitisation
test carried out as an adjuvant test according to the Magnusson &
Kligman Maximisation test method, using 10 test and 5 control animals in
the main test. Following the induction exposure to the test article (50%
in petrolatum) or the vehicle petrolatum (control article), the animals
of both groups were subjected two weeks later to a challenge exposure
with the test article (50% in petrolatum) as well as the control
article. Responses to the challenge procedure were evaluated 24 and 48
hours after the end of the exposure period.
Results: -No allergic skin reactions occurred in test animals 24 and 48
hours after the end of the challenge procedure. The sensitisation rate
-No findings were observed in control animals (reaction rate:0%).
Evaluation: According to the EEC Directive 2001/59/EEC, 6 August 2001
and the Gefahrstoffverordnung (GefStoffV) of 15 November 1999 (BGB1. I,
p.2233) test conditions described, the test article "LITHARGE lead
oxide" can be classified as a "non-sensitiser" since no allergic
responses were observed in test animals under the experimental
These results can be assigned to trilead bis(carbonate) dihydroxide since
a read across based on a grouping of substances (Pb substances) is
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