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EC number: 235-727-4
CAS number: 12626-81-2
According to the OECD Guideline for Testing of Chemicals, OECD
406, skin sensitisation on guinea pigs was tested for lead oxide (which
workers are most frequently exposed) and for lead phosphite (inorganic
compound with low water solubility).
In view of the lack of toxicity, irritation or reports of
sensitisation from occupational exposure settings, lead and sparingly
soluble lead compounds do not appear to pose risk of sensitisation and
the classification for these endpoints is not indicated.
These results can be assigned to lead titanium zirconium oxide since
a read across based on a grouping of substances (Pb substances) is
Migrated from Short description of key information:
The potential skin sensitising properties were assessed by using 10 test and 5 control animals in the main test. Following the induction exposure to the test article (50% in petrolatum) or the vehicle petrolatum (control article), the animals of both groups were subjected two weeks later to a challenge exposure with the test article (50% in petrolatum) as well as the control article. Responses to the challenge procedure were evaluated 24 and 48 hours after the end of the exposure period.
No allergic skin reactions occurred in test animals 24 and 48 hours after the end of the challenge procedure. The sensitisation rate was 0%
-No findings were observed in control animals (reaction rate: 0%).
No allergic skin reactions occurred in test
animals 24 and 48 hours after the end of the challenge procedure for
lead oxide, which can be assigned to lead titanium zirconium oxide. In
addition sparingly soluble lead compounds do not appear to pose risk of
sensitisation and the classification for these endpoints is not
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