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EC number: 231-176-9
CAS number: 7440-67-7
Both in the absence and presence of S9 -mix zirconium dioxide did not
induce a statistically significant or biologically relevant increase in
the number of cells with chromosome aberrations in two independent
No effects of zirconium dioxide on the number of polyploid cells and
cells with endoreduplicated chromosomes were observed both in the
absence and presence of S9 -mix. Therfore it can be concluded that
zirconium dioxide does not disturb mitotic processes and cell cycle
progression and does not induce numerical chromosome aberrations under
the experimental conditions of this test.
A chromosome aberration test was performed
according to OECD guideline 473. Cultured peripheral human lymphocytes
were exposed for 3 hours to 10, 33 and 100 µg zirconium dioxide/mL
culture medium with and without S9-mix (dose range finding test/first
cytogenetic assay); at 24 and 48 h continuous exposure time blood
cultures were treated with 1, 3, 10, 33, 100, 333 and 1000 µg zirconium
dioxide/mL culture medium without S9-mix. A second cytogenicity test was
performed as follows: without S9-mix: 10, 33 and 100 µg/mL culture
medium (24 and 48h exposure time, 24h and 48h fixation time); with
S9-mix: 10, 33 and 100 µg/mL culture medium (3h exposure time, 48h
fixation time). Vehicle and positive control substances were tested
simultaneously and considered valid. Zirconium dioxide tested negative
with and without metabolic activation. No cytotoxicity was observed.
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