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EC number: 231-176-9
CAS number: 7440-67-7
Two groups, each of three female WISTAR Crl: WI(Han) rats, were treated
with Zirconium by oral gavage administration at a dosage of 2000 mg/kg
body weight.The animals were observed on delivery, on inclusion in the
study and before administration for mortality/morbidity and other
clinical signs. All animals were examined for clinical signs several times
on the day of dosing and once daily until the end of the observation
period. Their body weights were recorded on day 1 (prior to the
administration) and on days 8 and 15.
All animals were necropsied and examined macroscopically. Throughout the
14-day observation period, all animals survived until the end of the
study without showing any signs of toxicity.In conclusion, the median
lethal dose of Zirconium after a single oral administration to female
rats, observed over a period of 14 days is 5000 mg/kg body weight (LD50
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