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EC number: 231-176-9 | CAS number: 7440-67-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study without any deviations
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Zirconium
- EC Number:
- 231-176-9
- EC Name:
- Zirconium
- Cas Number:
- 7440-67-7
- Molecular formula:
- Zr
- IUPAC Name:
- zirconium
- Details on test material:
- Purity: > 99.4%
Density: 6.5 g/cm³
Colour: grey
Physical State at RT: solid, powder (< 0.1 mm)
Storage: at room temperature, in a tightly closed package
Stability in Container after Opening: stable
Safety Precautions: Beside routine hygienic procedures additional actions will be taken to assure personnel health and safety, such as
- Powder was stored and handled under Argon gas
- No water was used for any of the dose preparations
- Personal protective equipment was used while handling the substance
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Females were non-pregnant and nulliparous.
Age at the beginning of the study: approximately 8 - 9 weeks old
Body weight at the beginning of the study: animals no. 1 – 3, step 1: 159 – 177 g; animals no. 4 – 6, step 2: 161 – 168 g;
The animals were derived from a controlled full-barrier maintained breeding system (SPF).
Housing and feeding conditions:
Full barrier in an air-conditioned room
- Temperature: 22 3 °C
- Relative humidity: 55 +/-10%
- Artificial light, sequence being 12 hours light, 12 hours dark
- Air change: 10 x / hour
- Free access to diet and tap water
- The animals were kept in groups in IVC cages
- Certificates of food, water and bedding are filed at BSL BIOSERVICE
- Adequate acclimatisation period (at least five days)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- The test item was administered at a single dose by gavage using a feeding tube.
The test item was administered at a dose volume of 5 mL/kg body weight.
Details on test item preparation
A solubility test was performed with the vehicle corn oil. No solubility was achieved, but a suspension applicable to the animals. Homogeneity of the test item in the vehicle was maintained by shaking the prepared suspension thoroughly before every dose administration.
For all animals of the first and second step, 2 g of the test item were suspended in the vehicle to gain a final volume of 5 mL and to achieve a dose of 2000 mg/kg body weight at a dose volume of 5 mL/kg body weight.
The dose formulations were made shortly before each dosing occasion. - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 3 per step
- Control animals:
- no
- Details on study design:
- The starting dose was selected to be 2000 mg/kg body weight. No compound related mortality was recorded for any animal of step 1 or 2. Based on these results and according to the acute toxic class method regime no further testing was required.
- Statistics:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD0
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: LD50 cut off
- Mortality:
- no mortality
- Clinical signs:
- other: no signs of toxicity observed
- Gross pathology:
- With the exception of acute injection of blood vessels in the abdominal region, which is due to the euthanasia injection, no specific gross pathological changes were recorded for any animal
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the condition of this test, a single oral application of Zirconium Powder to rats at a dose of 2000 mg/kg body weight was associated with no signs of toxicity or mortality. The median lethal dose of Zirconium Powder after a single oral administration to female rats, observed over a period of 14 days, is 5000 mg/kg body weight.
- Executive summary:
Two groups, each of three female WISTAR Crl: WI(Han) rats, were treated with Zirconium by oral gavage administration at a dosage of 2000 mg/kg body weight.The animals were observed on delivery, on inclusion in the study and before administration for mortality/morbidity and other clinical signs. All animals were examined for clinical signs several times on the day of dosing and once daily until the end of the observation period. Their body weights were recorded on day 1 (prior to the administration) and on days 8 and 15.
All animals were necropsied and examined macroscopically. Throughout the 14-day observation period, all animals survived until the end of the study without showing any signs of toxicity.In conclusion, the median lethal dose of Zirconium after a single oral administration to female rats, observed over a period of 14 days is 5000 mg/kg body weight (LD50 cut off).
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