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EC number: 231-176-9
CAS number: 7440-67-7
The acute inhalation toxicity of zirconium dioxide was evaluated
in a 4-hour, single‑exposure study in rats. Zirconium dioxide was
administered to 1 group of 3 male and 3 female Crl:CD(SD) albino rats
via nose-only inhalation exposure as a dust aerosol at a concentration
of 4.3 mg/L. The exposure atmosphere was characterized by a mean mass
median aerodynamic diameter (± geometric standard deviation) of 2.0 µm ±
1.75 µm. Mortality, clinical observations, body weights, and body weight
changes were evaluated over a 14-day post-exposure observation
period. Necropsies were conducted on all animals.
Mortality was 0/6 animals for the 4.3 mg/L group. There were no
significant clinical observations immediately following
exposure. Significant clinical observations for animals during the
14-day post-exposure observation period included decreased defecation
and small feces. All animals were considered clinically normal by study
day 3. All animals lost weight from study day 0 to 1. One male lost
weight (9 grams) from study day 1 to 3. All animals surpassed their
initial (study day 0) body weight by study day 14. There were no
macroscopic findings for any animal at the scheduled necropsy.
Based on the results of this study, the LC50 of zirconium dioxide
was greater than 4.3 mg/L, the maximum obtainable mean concentration,
when male and female albino rats were exposed to a dust aerosol of the
test substance as a single, 4-hour, nose-only exposure.
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