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EC number: 231-176-9
CAS number: 7440-67-7
Tests in bacterial
systems are not appropriate for metal due to a lack of sensitivity
related to either probable mechanism of action or lack of metal uptake.The
high prevalence of false negatives for metal compounds might suggest
that mutagenesis essay with mammalian cells, as opposed to bacterial
cells, would be preferred starting point.
Although no data is
available on the genotoxic potential of metallic zirconium, one may
safely assume that metallic zirconium as such cannot cross cellular
membranes, but instead only the zirconium cation, the active form.
Therefore, read across with reference to information on the mutagenicity
of other zirconium substances (like ZrO2) is clearly warranted.
An in vitro
cytogenicity study in mammalian cells with ZrO2 (according to OECD 473
guideline) and vitro gene mutation study in mammalian cells with ZrO2
(OECD 476 guideline) were realised. The soluble Zr cation, the active
form, was tested, so the results could be used to read across. The
result of the two tests performed with ZrO2 was negative: under the
experimental conditions, no chromosome aberration or gene mutation was
induced in mammalian cells.
Based on the
available data, the substance was not classified under the CLP
Regulation 1272/2008 and the directive Classification and Labelling
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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