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EC number: 231-176-9
CAS number: 7440-67-7
No data is available for skin irritation/corrosion or eye irritation on Zr substance ; read across with ZrO2 data is performed. Due to its inert property, the substance is neither a skin irritant, nor an eye irritant. These results are confirmed by different key studies.
According to the REACh
recommendations for the DNEL derivation (Guidance on information
requirements and chemical safety assessment Chapter R.8:
characterisation of dose (concentration)-response for human health), a
read across could be used for substances with similar behaviour and
toxic effects in the organism. Regarding the unstable properties of pure
zirconium, studies have demonstrated that, outdoor, a stable passivation
layer is formed on the zirconium metal: this very thin oxide layer grows
rapidly. Actually, the rapid oxidation of zirconium metal into ZrO2 and
the high stability of the latter form make the zirconium dioxide the
best candidate to assess the toxicity of zirconium. Both compounds are
such insoluble and are considered inert. Read across to ZrO2 is
Two reliable studies,
performed with ZrO2, have been identified (Klimisch 2). The study of
Magnesium Elecktron Ltd (1986) is a GLP study, performed according to
the OECD 404 guideline with minor deviations. The substance was
determined not to be irritating to New Zealand White rabbit skin after 4
hours of exposure. These observations were supported by the Tosoh study
(2000). This second GLP study followed also the OECD guideline 404 and
the result is “not irritating”.
A reliable study was
performed (Tosoh, 2000 – Klimisch 2) in New Zealand White rabbit. The
test substance was determined to be slightly irritating based on the
AFNOR criteria. Observed effects were fully reversible within 72
hours.The slight irritation observed in the study performed with ZrO2,
after 48 hours, is due to a mechanical action of the powder applied on
Based on the available data, the
substance was not classified under the CLP Regulation 1272/2008 and the
directive Classification and Labelling 67/548.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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