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EC number: 211-989-5
CAS number: 732-26-3
Table 2: Individual Scores for Ocular Irritation
Examination Interval (hours)
Degree of opacity
The irritancy potential of the test material was investigated in a study
conducted in accordance with the standardised guidelines OECD 405 and EU
Method B.5 under GLP conditions.
A single application of the neat test material was made to the
non-irrigated eye of three New Zealand White rabbits. One rabbit was
initially treated. Immediately after administration of the test material
an assessment of the initial pain reaction was made.
After consideration of the ocular responses produced in the first
treated animal, two additional animals were treated. In order to
minimise pain on installation of the test material, one drop of local
anaesthetic (Ophthaine, 0.5 % proxymetacaine hydrochloride) was
instilled into both eyes of the third animal 1 to 2 minutes before
Assessment of ocular damage/irritation was made approximately 1 hour and
24, 48 and 72 hours following treatment, according to the Draize scale.
Any other adverse ocular effects were also noted.
No adverse corneal effects were noted during the study. Iridial
inflammation was noted in two treated eyes one hour after treatment; no
other adverse iridial effects were noted. Minimal conjunctival
irritation was noted in all treated eyes one hour after treatment and in
two treated eyes at the 24-hour observation. No adverse ocular effects
were noted 24 to 48 hours after treatment.
Under the conditions of this study the test material was found to be non
irritating to the eye.
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