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EC number: 211-989-5
CAS number: 732-26-3
The 48 h EC50 was determined to be >0.072 mg/L.
There are two studies available to address this endpoint, one key and
In the key study, the acute toxicity of the test material to daphnia
magna was investigated in a study conducted in accordance with the
standardised guidelines OECD 202, EU Method C.2 and the Guidance
document on aquatic toxicity testing of difficult substances and
mixtures, OECD series on testing and assessment number 23 under GLP
conditions. The study was assigned a reliability score of 1 in line with
the principles for assessing data quality as defined by Klimisch et al.
A combined limit/range-finding test was performed. A Water Soluble
Fraction (WSF) prepared at a loading rate of 100 mg/L was used as the
highest concentration. The lower test concentrations were prepared by
subsequent dilutions of the highest concentration in test medium. The
final test solutions were all clear and colourless.
Twenty daphnids per group (5 per replicate, quadruplicate) were exposed
to an untreated control and to an undiluted WSF in a limit test. In
addition, ten daphnids per group (5 per replicate, duplicate) were
exposed to solutions containing 1.0 and 10 % WSF, in the combined
range-finding test. The total exposure period was 48 hours and samples
for analytical confirmation of exposure concentrations were taken at the
start and at the end of the test. The exposure vessels were closed
airtight and the headspace was reduced to a minimum.
Samples taken from the limit concentration were analysed. The actual
concentration measured at the start of the test was 0.072 mg/L. The
measured concentration remained stable during the exposure (96 % of
initial). Therefore, the effect parameters were expressed in terms of
No effects were observed in any of the groups tested.
Under the conditions of this study, the 48 h EC50 exceeded a measured
concentration of 0.072 mg/L, being considered the maximum solubility of
the test material in medium.
In the supporting study, the toxicity of the test material to the
daphnid was estimated using the ECOSAR model v1.11 (EPI Suite v4.11).
The study was awarded a reliability score of 2 in line with the
principles for assessing data quality as defined by Klimisch et al.
The structure-activity relationships (SARs) presented in this program
are used to predict the aquatic toxicity of chemicals based on their
similarity of structure to chemicals for which the aquatic toxicity has
been previously measured. Most SAR calculations in the ECOSAR Class
Program are based upon the octanol/water partition coefficient
(Kow). The toxicity of the test material to daphnids was estimated using
the Phenols class of ECOSAR. The molecular weight of the test material
is within the training set range.
The estimated 48 hour LC50 was 0.045 mg/L.
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