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EC number: 211-989-5
CAS number: 732-26-3
Table 1: Effect of the Test Material in the Diet on
Benzo(a)pyrene-induced Neoplasia of the Forestomach in Female Mice
Dose Group (mmol/g in the diet)
No. of Mice
Weight Gain from 63 to 211 days of Age (g)
Tumours of the Forestomach
Percentage of Mice with Tumours
No. of Tumours / Mouse*
No. of Tumours per Mouse (test / control)
4.8 ± 0.5
5.9 ± 0.7
*Number of tumours occurring in the entire group divided
by the number of mice at risk
The study was conducted to investigate the inhibitory effects of 18
synthetic phenolic compounds, including the test material, on
benzo(a)pyrene-induced neoplasia of the forestomach of female ICR/Ha
The investigation was designed to explore the relationships between the
chemical structure of phenols and their potency as inhibitors of
Female mice were exposed to the test material in the diet for
approximately 5 and a half weeks, along with the carcinogen
benzo(a)pyrene. At the end of the experiment, any tumour suppression
caused by the test material was evaluated.
The test material was determined to be ineffective as an inhibitor of
tumour formation. Some of the other materials studied did exhibit
inhibitory properties; however, analysis of the structures and activity
determined that substitution of a third tert-butyl group para to the OH
totally destroys the inhibitory activity. In general, 3 or more
substitutions on the phenol ring render the molecule inactive as an
Under the conditions of this study, the test material did not exhibit an
inhibitory effect on benzo(a)pyrene-induced neoplasia.
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