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EC number: 265-042-6
CAS number: 64741-42-0
A complex combination of hydrocarbons produced by distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly in the range of C4 through C11 and boiling in the range of approximately minus 20°C to 220°C (-4°F to 428°F).
Light catalytically cracked naphtha was administered once
daily to pregnant rats on gestation days 0-19 via dermal application at
doses of 30, 125, and 500 mg/kg to assess for developmental
toxicity. Maternal parameters (food consumption, body weight gain, serum
chemistry) were monitored throughout gestation and were not adversely
affected by treatment. No adverse effects were observed on eproductive
parameters (number of implants, resporptions, or viable fetuses) or on
fetal parameters (body weight or crown:rump length). No evidence of
teratogenicity was observed in fetues from pregant dams exposed to the
test material. Based on the study results, the maternal NOAEL and the
teratogenicity NOAEL were greater than 500mg/kg. These findings do not
warrant the classification of light catalytically cracked naphtha as a
developmental hazard under Regulation (EC) 1272/2008 on classification,
labeling, and packaging of substances and mixtures (CLP) or under the
Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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