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EC number: 265-042-6
CAS number: 64741-42-0
A complex combination of hydrocarbons produced by distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly in the range of C4 through C11 and boiling in the range of approximately minus 20°C to 220°C (-4°F to 428°F).
Skin irritation – Irritating in rabbit (OECD TG 404). Mean erythema score (5 treated animals; 24, 48, 72 hr average): 2.56.
Eye irritation – Not irritating in rabbit (OECD TG 405). Mean conjunctival score (24, 48, 72 hour average): 0.05.
The human literature indicates that
gasoline and naphtha blending stocks produce some dermal irritation but
do not appear to be severe dermal irritants or corrosive agents. There
is some evidence of eye irritation associated with vapor exposure at
levels equal to and greater than 200 ppm, but the effects were mild, and
the dose-response information was not conclusive. Similarly,
gasoline and naphtha blending stocks produced some dermal irritation but
not corrosion when applied to rabbit skin. The
level of irritation was enhanced when the test materials were applied
under occluded patch. In-vitro
irritation assays confirm that gasoline naphthas are not corrosive.
There was very little evidence of irritation when these materials were
instilled into rabbit eyes.
Justification for selection of skin irritation / corrosion endpoint:
One of a large number of in-vivo skin irritation studies with a range of naphtha substances, all of which show similar results. Suuported by a large number of in-vitro studies
Justification for selection of eye irritation endpoint:
One of a large number of eye irritation studies on gasoline naphthas, all of which show similar results
Effects on skin irritation/corrosion: irritating
The animal studies were conducted under
regulatory guidelines and in accordance with good laboratory practice
data can be used without restriction for regulatory purposes and support
classification of gasoline and naphtha blending stocks as Skin Irritant
2 according to EU CLP Regulation (EC No. 1272/2008).
Gasoline and naphtha blending stocks do
not meet the criteria for classification as an eye irritant according to
the EU CLP Regulation (EC No. 1272/2008).
There is no need to conduct additional
animal testing for these endpoints.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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