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EC number: 265-042-6
CAS number: 64741-42-0
A complex combination of hydrocarbons produced by distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly in the range of C4 through C11 and boiling in the range of approximately minus 20°C to 220°C (-4°F to 428°F).
Exposure to high levels of gasoline can produce acute central nervous system depression in humans and experimental animals.
Repeated exposure at lower, occupational levels of gasoline produced little evidence of chronic neurological effects in humans or in experimental animals.
Both the human and animal data indicate
that exposure to high levels of gasoline can produce acute central
nervous system depression. There
is also evidence from the clinical literature that repeated exposure to
gasoline at very high levels, under abuse conditions, can produce more
profound central nervous system effects. Less
clear is the degree to which these effects may have been due to the lead
additives as opposed to the hydrocarbon constituents. There
is little evidence of chronic neurological effects in humans exposed
repeatedly at lower, occupational levels. The
animal data provide little experimental support for chronic neurological
effects from either unleaded gasoline or naphtha blending stocks. Initial
studies with wholly vaporized unleaded gasoline provided evidence of
exacerbation of normal, age-related changes. However,
subsequent studies with gasoline vapor and naphtha blending stocks had
no clear or reproducible effects on motor activity, produced no
functional changes, and did not induce histological changes in the
nervous system. It
is not known to what extent the differences between these studies, if
real, were due to differing experimental conditions (i.e., subchronic
versus chronic exposures) or specific constituents contributing to
exposure (gasoline vapor versus wholly vaporized gasoline).
Justification for selection of effect on neurotoxicity via inhalation route endpoint:
one of 3 studies investigating the neurotoxicity of gasoline
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