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EC number: 265-042-6
CAS number: 64741-42-0
A complex combination of hydrocarbons produced by distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly in the range of C4 through C11 and boiling in the range of approximately minus 20°C to 220°C (-4°F to 428°F).
Unleaded gasoline vapor was administered by inhalation to
Fischer 344 rats and B6C3F mice for 6 hours/day, 5 days/week for up to
113 weeks at analytical vapor concentrations of 322, 1402, and 9869 mg/m3to
assess inhalation toxicity. No consistent, compound-related changes were
seen in mortality, hematology or clinical chemistry parameters in either
species. Significant depression of body weight gain was seen in both
sexes of rats and male mice exposed to the highest level of gasoline
vapor. On gross necropsy, a compound-related increase in liver nodules
and masses was seen in female mice exposed to the highest dose level. In
addition, male rats exposed to gasoline vapor at all concentrations
exhibited primary kidney neoplasms, correlated histopathologically with
an increase in the incidence and severity of regenerative epithelial
changes and dilated tubules containing proteinaceous material. The
kidney effects observed in male rats are indicative of alpha-2u-globulin
nephropathy. Alpha-2u-globulin nephropathy, also known as hyaline
droplet nephropathy, results from the formuation of complexes with a
naturally occurring protein (alpha-2u-globulin) in the kidneys of male
rats. These complexes can accumulate in the proximal renal tubule and
may produce species-specific histopathological changes. Based on the
decreased body weight gain at the highest dose, the no observed adverse
effect concentration (NOAEC) was 1402 mg/m3.
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