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EC number: 265-042-6
CAS number: 64741-42-0
A complex combination of hydrocarbons produced by distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly in the range of C4 through C11 and boiling in the range of approximately minus 20°C to 220°C (-4°F to 428°F).
Four naphtha streams, among fifteen hydrocarbon
compounds, were administered to two groups of male Fischer 344 rats by
oral gavage at the dose levels of 500 mg/kg/day and 2000 mg/kg/day five
days per week for four weeks. The procedure was designed to investigate
hydrocarbon nephropathy. Animals in both groups experienced lethargy and
significantly lower body weight gain was observed in the animals at the
high-dose group. The
only histopathological difference found was in the kidneys of all male
rats. The kidney effects observed in male rats are indicative of
alpha-2u-globulin nephropathy. These kidney effects are specific to male
rats and are not considered to be of biological relevance to humans. Unleaded
gasoline induced a strong nephrotoxic response.
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