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EC number: 265-042-6
CAS number: 64741-42-0
A complex combination of hydrocarbons produced by distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly in the range of C4 through C11 and boiling in the range of approximately minus 20°C to 220°C (-4°F to 428°F).
Baseline gasoline vapor condensate was examined for its potential to
induce chromosomal damage in rat bone marrow erythrocytes from rats
dosed via inhalation with the test material at 2000, 10 000, or 20 000
mg/m3 for 6 hours per day, 5 days a week for a duration of 4
weeks. Vehicle control animals were dosed with clean air alone, and
positive control animals were dosed intraperitoneally with 40 mg/kg dose
of cyclophosphamide in sterile water. Bone marrow was collected from 10
animals (5/sex) from each treatment and control group at 24 hours after
the final administration. No statistically significant increases in the
frequency of micronucleated immature erythrocytes and no substantial
decrease in the proportion of immature eyrthrocytes were observed in the
dose groups treated with the test material compared to the negative
control values (p>0.01 in each case). The positive control
material caused both large, significant increases in the frequency of
micronucleated immature erythrocytes and statistically significant
decreases in the proportion of immature erythrocytes (p<0.001 in
each case). Baseline gasoline vapor condensate was considered to be
non-genotoxic and non-clastogenic under the conditions of this test.
This finding does not warrant classification of baseline gasoline vapor
condensate as a genotoxin under Regulation (EC) 1272/2008 on
classification, labeling, and packaging of substances and mixtures (CLP)
or under the Directive 67/518/EEC for dangerous substances and Directive
1999/45/EC for preparations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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