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EC number: 203-051-9
CAS number: 102-76-1
Acute toxicity: Oral LD50 (rat, m/f): > 2000 mg/kg bw (OECD 401, GLP)Acute toxicity: Inhalation LC50 (rat, m/f): > 1.7 mg/L (OECD 403, GLP)
Acute oral toxicity:
An acute oral toxicity study (limit test) with Triacetin (CAS 102-76-1)
was performed according to OECD Guideline 401 and GLP (Reijnders, 1988).
The test substance was administered by oral gavage at a concentration of
2000 mg/kg bw to groups of five male and female young adult Wistar rats.
The animals were observed for 14 days following administration. No
mortalities occurred during the study period. No clinical signs of
toxicity and no changes in body weight were reported. Necropsy at the
end of the 14-day study period did not reveal any substance related
findings. The acute oral LD50 was found to be greater than 2000 mg/kg bw
for the substance.
In another study (Lawrence, 1974), graded dose levels of Triacetin (0.5,
1, 2, 4, 8, and 16 mL/kg bw equivalent to 580.5, 1161, 2322, 4644, 9288
and 18576 mg/kg bw) were administered by oral gavage to groups of two
mice, and the acute LD50 was calculated by Cornfield and Mantel’s
modification of Karber’s method, or by the method of Weil, based upon
mortalities within a 7-day observation period. The acute oral LD50 for
mice was reported to be 8 mL/kg bw, corresponding to 9250 mg/kg bw of
Acute inhalation toxicity:
An acute nose/head only inhalation toxicity study was performed with
Triacetin (CAS 102-76-1) similarly to OECD Guideline 403 and under GLP
conditions (Pauluhn, 1985). Five male and five female Wistar rats were
exposed for 4 hours to the maximum attainable Triacetin aerosol
concentration of 1.7 mg/L (analytical concentration). The nominal
concentration used in this study was 20 mg/L. Samples taken from the
breathing zone were used to measure the actual Triacetin concentration.
100 % of the aerosol particles were found to be smaller than 5 µm and
the MMAD was 1.69 µm. All treated animals survived and no signs of
systemic toxicity were observed throughout the 14-day observation
period. No local irritation of the visible mucous membranes of the
respiratory tract was seen at gross pathology analysis. The acute
inhalation LC50 in rats was found to be greater than the maximum
attainable aerosol concentration of 1.7 mg/L Triacetin. This
concentration is above the maximum saturated vapour concentration of
Triacetin, which is 0.5986 mg/L at 20°C.
Acute dermal toxicity:
The acute dermal toxicity of Triacetin (CAS 102 -76 -1) was tested in
groups of five albino rabbits administered a single dose of 5000 mg/kg
bw of the substance to the intact and abraded skin (Fiume, 2003).
According to the authors, none of the rabbits died during the
observation period of 7 days after administration. However, as the
original study report was not available, but only referenced as short
information in a review article, this study was not taken into further
account for hazard assessment.
The available data on acute oral and inhalation toxicity of the
substance do not meet the criteria for classification according to
Regulation (EC) 1272/2008 or Directive 67/548/EEC, and are therefore
conclusive but not sufficient for classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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