Registration Dossier
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EC number: 203-051-9 | CAS number: 102-76-1
Endpoint summary
Administrative data
Description of key information
Additional information
Studies investigating the terrestrial toxicity of triacetin (CAS 102-76-1) are not available. Due to the properties of triacetin a hazard to soil organisms is assumed to be low.
Acute and chronic study results proved that triacetin has only a low toxicity in mammals and aquatic organisms. For humans Fatty Acid Glycerides like triacetin constitute a large part of the fat content within the diet. They participate in normal physiological processes and are thus inherently harmless. The common metabolic fate of triacetin involves stepwise hydrolysis to acetic acid and free glycerol (Barry et al. 1966). Acetic acid and glycerol feed into physiological pathways like the citric acid cycle, sugar synthesis and lipid synthesis. Furthermore glycerol is a part of membrane lipids and thus present in all living organism.
Natural occurring triglycerides, like triacetin, are energy source for all living organisms. They are synthesised by plants and stored in the fatty tissue of organisms. Also in microorganisms inclusion of fat droplets is common. Fungi, for example, store triglycerides in vacuoles. Thus, as triglycerides like triacetin are constituents of terrestrial macro and micro-organisms, and naturally produced by plants, toxic effects caused by triacetin are implausible. Moreover, as Triacetin is readily biodegradable and has a log Kow < 3 (0.25), an indirect exposure of soil organisms through sludge application can be ruled out.
Hence, considering the lack of indirect exposure via sludge and the most likely harmlessness of triacetin for terrestrial organisms, no soil toxicity data have to be generated.
References:
Barry, R.J.C. et al. (1966). Handling of glycerides of acetic acid by rat small intestine in vitro. J. Physiol., 185: 667-683.
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