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EC number: 203-051-9
CAS number: 102-76-1
Studies investigating the terrestrial toxicity of triacetin (CAS
102-76-1) are not available. Due to the properties of triacetin a hazard
to soil organisms is assumed to be low.
Acute and chronic study results proved that triacetin has only a low
toxicity in mammals and aquatic organisms. For humans Fatty Acid
Glycerides like triacetin constitute a large part of the fat content
within the diet. They participate in normal physiological processes and
are thus inherently harmless. The common metabolic fate of triacetin
involves stepwise hydrolysis to acetic acid and free glycerol (Barry et
al. 1966). Acetic acid and glycerol feed into physiological pathways
like the citric acid cycle, sugar synthesis and lipid synthesis.
Furthermore glycerol is a part of membrane lipids and thus present in
all living organism.
Natural occurring triglycerides, like triacetin, are energy source for
all living organisms. They are synthesised by plants and stored in the
fatty tissue of organisms. Also in microorganisms inclusion of fat
droplets is common. Fungi, for example, store triglycerides in vacuoles.
Thus, as triglycerides like triacetin are constituents of terrestrial
macro and micro-organisms, and naturally produced by plants, toxic
effects caused by triacetin are implausible. Moreover, as Triacetin is
readily biodegradable and has a log Kow < 3 (0.25), an indirect exposure
of soil organisms through sludge application can be ruled out.
Hence, considering the lack of indirect exposure via sludge and the most
likely harmlessness of triacetin for terrestrial organisms, no soil
toxicity data have to be generated.
Barry, R.J.C. et al. (1966). Handling of glycerides of acetic acid by
rat small intestine in vitro. J. Physiol., 185: 667-683.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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