Triacetin

Additional toxicological data

Administrative data

Endpoint:

additional toxicological information

Type of information:

other: review

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: only secondary literature: GRAS notification from Select Committee of Food and Drug Administration

Data source

Reference

Reference Type:

review article or handbook

Title:

Unnamed

Year:

1975

Materials and methods

Test material

Test material information

Constituent 1

Reference substance name:

Triacetin

EC Number:

203-051-9

EC Name:

Triacetin

Cas Number:

102-76-1

Molecular formula:

C9H14O6

IUPAC Name:

1,3-bis(acetyloxy)propan-2-yl acetate

Results and discussion

Any other information on results incl. tables

Triacetin, acetooleins, acetostearins Triacetin and two types of acetooleins have been found to be without toxic effects in long-term feeding tests in rats at levels that were several orders of magnitude greater than those to which consumers are exposed. Three types of acetostearins have been found to be without toxic effects in long-term feeding tests in rats at levels up to 5 g per kg per day. This contrasts with an estimated human consumption of a fraction of a milligram per kg per day. It is recognized that at an even higher feeding level (10 g per kg per day) male rats developed testicular atrophy and female rats, uterine discoloration. However, such a level which would amount to 50 g or more for an infant and 600 g for an adult per day, is vastly higher than would be possible in the consumption of foods to which acetostearins are added for functional purposes. In light of the available scientific information the Select Committee concludes that: There is no evidence in the available information on triacetin, acetooleins, and acetostearins that demonstrates or suggests reasonable grounds to suspect a hazard to the public when they are used at levels that are now current or that might reasonably be expected in the future.

Applicant's summary and conclusion

Conclusions:

There is no evidence in the available information on triacetin that demonstrates or suggests reasonable grounds to suspect a hazard to the public.