Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-051-9
CAS number: 102-76-1
The acetate released appeared in higher concentrations on the serosal
side: when 100 µmoles of acetate were initially present in the mucosal
- the mucosal transfer was 38 µmoles (diminution in the volume on the
- the serosal transfer was 19 µmoles (increase in volume inside the sac)
- the final mucosal conc. was 4.48 mM
- the final serosal conc. was 9.96 mM
With increasing concentrations of mono-, di- and triacetin (5, 10 and 15
mM), the amount of acetate release increased linearly up to about a
total amount of 300 µmoles of acetates release.
With increasing number of acetic acid residues, the amounts of released
acetate increased: when mono-, di- and triacetin (15 mM) were hydrolysed
92, 206 and 307 µmmoles of acetate were released, respectively.
Extent of hydrolysis of acetins:
The rate-limiting step of acetin hydrolysis was the entry of glyceride
into the epithelial cell.
Site of hydrolysis:
No hydrolytic activity could be detected in the mucosal or serosal
fluids at the end of the incubation, so that this activity depends on
the presence of intestinal tissue. The results indicate that the acetate
is released on the 'cell' side of a diffusion barrier, and is in this
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Ce site web utilise des cookies afin de vous garantir la meilleure expérience possible sur nos sites web.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again