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EC number: 203-051-9
CAS number: 102-76-1
In a combined repeated dose and reproductive/developmental toxicity
screening test according to OECD Guideline 422, rats received oral
gavage doses up to 1000 mg/kg bw/day of triacetin for 44 days from 2
weeks prior to mating for males and for 41- 48 days from 14 days before
mating to day 3 postpartum for females.
Triacetin had no effects on clinical signs, body weight, food
consumption, and organ weight or necropsy findings. No abnormalities in
haematological or blood chemical parameters in males were found. No
histopathological changes were observed in either sex. The NOAEL for
repeated dose oral toxicity is thus considered to be 1000 mg/kg bw/day
for both sexes.
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