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EC number: 257-913-4 | CAS number: 52434-90-9
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: non GLP study
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Sample was characterized in terms of particle size by Single Particle Optical Sensing (SPOS)
- Type of method:
- other: Single Particle Optical Sensing (SPOS)
- Type of particle tested:
- primary particle
- Type of distribution:
- volumetric distribution
- Percentile:
- D10
- Mean:
- 7.6 µm
- St. dev.:
- 1.34
- Percentile:
- D50
- Mean:
- 16.2 µm
- St. dev.:
- 1.34
- Percentile:
- D90
- Mean:
- 29.4 µm
- St. dev.:
- 1.34
- Percentile:
- other: Dmean
- Mean:
- ca. 17.7 µm
- St. dev.:
- 1.34
- Conclusions:
- The sample was characterized in terms of particle size by Single Particle Optical Sensing (SPOS) and the mean diameters at the 10%, 50% and 90% of the volume distribution are:
D10: 7,6 µm
D50: 16,2 µm
D90: 29,4 µm
with a mean value of 17.7 µm. - Executive summary:
About 10 mg exactly weighed of powder were suspended in 3 mL of a 0.1% Tween 20 aqueous solution, previously filtered by a 0.2 Pm membrane filter (VWR International, I). Samples were characterized in terms of particle size by Single Particle Optical Sensing (SPOS) using an Accusizer 770 (PSS Inc. USA). Particle size was expressed as undersize cumulative percentage of the volume distribution and the population dispersity was referred as span and calculated as reported in the following equation: span = (d90 − d10)/ d50
where d10, d50 and d90 represent the mean diameters at the 10%, 50% and 90% of the volume distribution, respectively.The results are the following: D10: 7,6 µm; D50: 16,2 µm; D90: 29,4 µm; mean value of 17.7 µm.
Reference
Description of key information
The sample was characterized in terms of particle size by Single Particle Optical Sensing (SPOS) and the mean diameters at the 10%, 50% and 90% of the volume distribution are:
D10: 7,6 µm
D50: 16,2 µm
D90: 29,4 µm
with a mean value of 17.7 µm.
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