Registration Dossier
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EC number: 257-913-4 | CAS number: 52434-90-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November 1976
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: limited justification
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Consumer Product Safety Commission of the U.S.A. in The Code of Federal Regulations, Title 16, Section 1500.41
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,3,5-tris(2,3-dibromopropyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione
- EC Number:
- 257-913-4
- EC Name:
- 1,3,5-tris(2,3-dibromopropyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione
- Cas Number:
- 52434-90-9
- Molecular formula:
- C12H15Br6N3O3
- IUPAC Name:
- tris(2,3-dibromopropyl)-1,3,5-triazinane-2,4,6-trione
- Reference substance name:
- unknown impurities
- IUPAC Name:
- unknown impurities
- Test material form:
- solid: particulate/powder
Constituent 1
impurity 1
- Specific details on test material used for the study:
- Sample code n°: 507-43
Test animals
- Species:
- rabbit
- Strain:
- other: Albino rabbit
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- other: Distilled water
- Amount / concentration applied:
- 0.5 g of test item mixed with 0.5 ml of distilled water
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 72 hours
- Number of animals:
- not specified
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 72 h
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 72 h
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- None of the animals showed any observable response to treatment throughout the 72 hours observation period.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Sample 507-43 is not considered to be an irritant to rabbit skin.
- Executive summary:
Sample 507-43 was tested according to the procedure prescribed by the Consumer Product Safety Commission of the U.S.A. in The Code of Federal Regulations, Title 16, Section 1500.41, a transcript of which is attached as an Appendix to the full study report.
0.5 g of the sample 507-43 was mixed with 0.5 ml of distilled water before application to the skin of tested rabbits.
None of the animals showed any observable response to treatment throughout the 72 hours observation period.
Therefore, sample 507-43 is not considered to be an irritant to rabbit skin.
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