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EC number: 257-913-4
CAS number: 52434-90-9
Rats of the CFY strain, in the were starved overnight before treatment
The material was prepared as a 40% suspension in carn oil and
administered by oral intubation at the maximum practical dosage volume
in the full scale test of 40 ml/Kg bodyweight. Rats treated with the
vehicle alone (40ml/Kg) served as controls.
During the observation period of 14 days, a record was kept of all signs
of toxicity. All rats were sacrificed terminally and examined
macroscopically in an attempt to identify any target organs.
The results of preliminary range finding test indicated that the median
lethal oral dose (LD_50), was greater than 16 g/Kg bodyweight.
Dosing was then extended to a large group of rats (five males and five
females) in order to confirm this finding.
There were no mortalities.
igns of reaction to treatment observed shortly after dosing, included
lethargy and piloerection in all treated animals and control animals.
There signs were accompanied by decreased respiratory rate in eight rats
at the preliminary screen levels of 0.1, 0.4 and 1.0 g/kg and in all
rats at 16 g/kg. increased respiratory rate was observed in two rats at
each screening level of 0.4 and 1.0 g/kg. Abnormal body carriage
(hunched posture) was also observed in all rats at screening levels of
0.1, 0,4 and 1,0 g/kg and seven rats at 16 g/Kg.
Recovery of the treated rats, as judged by external appearance and
behavior, was apparently complete within eight days of treatment. This
observation was substantiated by normal bodyweight gains and normal
The acute median lethal oral dose (LD50) to rats of 507.43 was found to
Greater than 16 g/Kg bodyweight
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