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EC number: 257-913-4 | CAS number: 52434-90-9
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- Uses advised against
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- Endpoint summary
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
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- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: The Consumer Product Safety Commission of the U.S.A. in The Code of Federal Regulations, Title 16, Section 1500.42
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,3,5-tris(2,3-dibromopropyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione
- EC Number:
- 257-913-4
- EC Name:
- 1,3,5-tris(2,3-dibromopropyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione
- Cas Number:
- 52434-90-9
- Molecular formula:
- C12H15Br6N3O3
- IUPAC Name:
- tris(2,3-dibromopropyl)-1,3,5-triazinane-2,4,6-trione
- Reference substance name:
- unknown impurities
- IUPAC Name:
- unknown impurities
- Test material form:
- solid: particulate/powder
Constituent 1
impurity 1
- Specific details on test material used for the study:
- Sample code n°: 507-43
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Albino rabbit
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- 79 mg
- Observation period (in vivo):
- 14 days
- Number of animals or in vitro replicates:
- 6 animals
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 1
- Reversibility:
- fully reversible within: 1 day
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.72
- Max. score:
- 1
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritant / corrosive response data:
- The numerical scores awarded to the ocular reactions elicited by test sample 507-43 are given in section "Any other information on results incl. tables".
None of the animals gave a positive reaction. Mild conjunctival reactions (redness) were observed in all six animals.
Any other information on results incl. tables
The numerical scores awarded to the ocular reactions elicited by Sample 507-43 are presented in Table 1 below:
Animal No. | Region of eye | Day | Positive (+) or Negative (-) Result | |||||
1 | 2 | 3 | 4 | 7 | 14 | |||
1 | Cornea | 0 | 0 | 0 | 0 | 0 | 0 | - |
Iris | 0 | 0 | 0 | 0 | 0 | 0 | ||
Conjunctivae redness | 0 | 1 | 1 | 1 | 1 | 0 | ||
Conjunctivae chemosis | 0 | 0 | 0 | 0 | 0 | 0 | ||
2 | Cornea | 0 | 0 | 0 | 0 | 0 | 0 | - |
Iris | 0 | 0 | 0 | 0 | 0 | 0 | ||
Conjunctivae redness | 1 | 1 | 1 | 1 | 1 | 0 | ||
Conjunctivae chemosis | 1 | 0 | 0 | 0 | 0 | 0 | ||
3 | Cornea | 0 | 0 | 0 | 0 | 0 | 0 | - |
Iris | 0 | 0 | 0 | 0 | 0 | 0 | ||
Conjunctivae redness | 1 | 1 | 1 | 0 | 0 | 0 | ||
Conjunctivae chemosis | 0 | 0 | 0 | 0 | 0 | 0 | ||
4 | Cornea | 0 | 0 | 0 | 0 | 0 | 0 | - |
Iris | 0 | 0 | 0 | 0 | 0 | 0 | ||
Conjunctivae redness | 1 | 1 | 1 | 0 | 0 | 0 | ||
Conjunctivae chemosis | 0 | 0 | 0 | 0 | 0 | 0 | ||
5 | Cornea | 0 | 0 | 0 | 0 | 0 | 0 | - |
Iris | 0 | 0 | 0 | 0 | 0 | 0 | ||
Conjunctivae redness | 1 | 0 | 0 | 0 | 0 | 0 | ||
Conjunctivae chemosis | 0 | 0 | 0 | 0 | 0 | 0 | ||
6 | Cornea | 0 | 0 | 0 | 0 | 0 | 0 | - |
Iris | 0 | 0 | 0 | 0 | 0 | 0 | ||
Conjunctivae redness | 1 | 0 | 0 | 0 | 0 | 0 | ||
Conjunctivae chemosis | 0 | 0 | 0 | 0 | 0 | 0 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Sample 507-43 gave a negative result for eye irritation, according to the definition given in the Code of Federal Regulations of the U.S.A.
- Executive summary:
The procedure employed was that prescribed by The Consumer Product Safety Commission of the U.S.A. in The Code of Federal Regulations, Title 16, Section 1500.42, a transcript of which is attached as an Appendix to the full study report.
For the test, 79 mg of sample 507-43 was instilled into one eye of each six animals, while the untreated eye was used as concurrent control.
The numerical scores awarded to the ocular reactions elicited by 507-43 are given in Table 1: none of the animals gave a positive reaction and only mild conjunctival reactions were observed in all six animals.
Sample 507-43 gave a negative test for eye irritation, according to the definition given in the Code of Federal Regulations of the U.S.A.
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